發(fā)布日期：2017-10-30
10月27日，最新一期Science雜志編輯部發(fā)布了一則撤稿聲明，撤稿聲明顯示，2011年諾貝爾生理學(xué)或醫(yī)學(xué)獎(jiǎng)得主、德克薩斯西南醫(yī)學(xué)中心教授Bruce Beutler及其合作者2014年在Science雜志上發(fā)表的題為“MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses”的一文因?yàn)楹罄m(xù)的數(shù)據(jù)重復(fù)問(wèn)題，在Bruce Beutler主動(dòng)告知了Science雜志后對(duì)該文進(jìn)行撤稿處理。撤稿聲明還顯示，該論文的第一作者M(jìn)ing Zeng以及共同第二作者Xiaolei Shi仍然表示他們的實(shí)驗(yàn)結(jié)果沒(méi)有問(wèn)題而不同意撤稿，他們認(rèn)為這是因?yàn)閷?shí)驗(yàn)設(shè)計(jì)造成的問(wèn)題。非常值得注意的是，著名的華人生物學(xué)家、美國(guó)科學(xué)院院士陳志堅(jiān)（Zhijian J. Chen）教授在該論文也有署名。
2014年這篇Science論文主要報(bào)道了cGAS-STING信號(hào)通路（在抵抗病毒感染和細(xì)菌入侵的過(guò)程中所產(chǎn)生的游離DNA作為危險(xiǎn)信號(hào)能被DNA感受器cGAS所識(shí)別，是近年來(lái)天然免疫領(lǐng)域最重要的發(fā)現(xiàn)之一，有望未來(lái)獲得諾貝爾獎(jiǎng)）缺失導(dǎo)致了動(dòng)物2型T細(xì)胞非依賴性抗體反應(yīng)下降，如果識(shí)別RNA的RIG-I加上識(shí)別DNA的cGAS信號(hào)通路同時(shí)缺失，那么該反應(yīng)幾乎全部消失。這表明了病毒RNA和DNA信號(hào)在內(nèi)源性逆轉(zhuǎn)錄病毒依賴的適應(yīng)性免疫反應(yīng)都發(fā)揮關(guān)鍵作用。
撤稿聲明中提到的問(wèn)題是，這篇論文的Fig 1和3所呈現(xiàn)的數(shù)據(jù)在課題組后續(xù)重復(fù)實(shí)驗(yàn)中得不到很好的重復(fù)（詳見文末撤稿聲明原文）。
撤稿聲明原文如下：
Bruce Beutler has informed Science that experiments performed in his laboratory have failed to reproduce clearly the foundational observations of the 2014 article “MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses” （1）。 In contrast to data presented （Figs. 1 and 3）， he now finds that deficiency of MAVS and/or cGAS does not cause a robust decrease in type II T-independent B cell responses. At most, a decreased antibody response is observed in Stinggt/gt mice. Although some of the data shown in the paper may be correct, the core observations and conclusions are not. Beutler and a majority of coauthors have therefore requested retraction of the paper.
The editors nonetheless note that authors Ming Zeng and Xiaolei Shi stand by the findings of the paper. These authors do not agree to this retraction due to disagreement with the design of the reproduction experiments.
The editors have worked with the authors to determine the appropriate outcome and have decided retraction is appropriate in light of the lack of robustness of the main finding.
來(lái)源：BioArt
